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Allogeneic stem cell transplantation provides durable disease control in poor-risk chronic lymphocytic leukemia: long-term clinical and MRD results of the German CLL Study Group CLL3X trial.
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Although randomized, controlled studies have shown little or no benefit of TPN in well-nourished or slightly malnourished cancer patients undergoing treatments such as surgery, radiation, or chemotherapy, those patients with severe malnutrition prior to therapeutic interventions demonstrated improved outcomes following major elective surgery, major trauma, and, in some cases, bone marrow transplantation, when TPN was initiated preoperatively.
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He gave an answer that was a little more equivocal than I would have liked, focusing on individualized medicine, however this is both a very legitimate perspective and one that doesn't preclude the use of Total Therapy for those whose biology indicates likely success from that treatment approach.
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Omdal R, Husby G, Koldingsnes W "Intravenous and oral cyclophosphamide pulse therapy in rheumatic diseases: side effects and complications.
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There was significantly less toxicity in terms of leukopenia and infection, and in this small study (22 and 25 in both treatment arms), there was an equivalent rate of remission, relapse, and renal outcomes.
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The most recently approved treatments for ALL are biologic drugs that are tyrosine kinase inhibitors (TKIs).
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Also, early research suggests that taking cordyceps (Bailing capsules) twice daily for 9 months together with the -lowering drug enalapril improves kidney function and slow the progression of the disease in patients with declining kidney function after a transplant.
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