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What is the normal level of tacrolimus? Of 155 tacrolimus measurements, only 48.4% were found within the therapeutic range (5-10 ng/mL); 7.1% below and 44.5% with elevated levels.
What is the mechanism of action of tacrolimus? Mechanism of action Tacrolimus is a macrolide calcineurin inhibitor. In T-cells, activation of the T-cell receptor normally increases intracellular calcium, which acts via calmodulin to activate calcineurin.

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