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As the discontinuation rate was relatively low, and there was no significant difference among groups, it is unlikely that exclusion bias caused by early termination affected the efficacy results.

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Because we undertook several tests for interaction, this difference according to the severity of dementia, which was only moderately significant, may have arisen by chance and needs to be confirmed, particularly since the severity of dementia did not have a significant effect on the difference in the BADLS score that was observed with continued, as compared with discontinued, donepezil therapy or on the differences in SMMSE or BADLS scores observed with memantine therapy, as compared with placebo.

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Find out why Public Citizen and an expert in Alzheimer's disease from Johns Hopkins have asked the FDA to ban the recently approved Alzheimer's drug, Aricept 23, from the market.

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Fisher exact probability test was used to compare each active group to placebo.

For each drug except tacrine, the evidence consisted of 1 or more well-designed and well-executed randomized, controlled trials yielding consistent, directly applicable results for most of the outcomes.

To minimize reactions to acute, extensive inhibition of AChE, all subjects initially received one 5 mg donepezil tablet and one matching placebo tablet.

One small, open-label, non-randomized study suggests that taking olanzapine by orally dissolving tablets may induce less weight gain, but this has not been substantiated in a blinded experimental setting.

Several clinical trials of behavioral interventions were completed in the last 5 years with some notable successes.

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Interview-Based Impression of Change (CIBIC plus) scores significantly improved compared with placebo, and significantly fewer donepezil recipients had treatment failure according to Clinical Global Impression of Change scores.

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Central and peripheral anticholinergic adverse effects, such as constipation, urinary retention, dry mouth, blurred vision and cognitive deficits, are particularly troublesome for elderly patients ().

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