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Minocycline that was used as initial therapy in patients who tested positive for rheumatoid factor was superior to placebo (response rate, 65 percent, as compared with 13 percent for placebo ) and superior to hydroxychloroquine (60 percent vs.

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Patients with ulcerative colitis also have a high chance of experiencing other disorders, including inflammation of the joints (arthritis), inflammation of the vertebrae (spondylitis), ulcers in the mouth and on the skin, the development of painful, red bumps on the skin, inflammation of several areas of the eye, and various disorders of the liver and gallbladder.

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